Hey Ilan,
Glad to hear from you. Yes, I am familiar with it, and I know it is popular because many exchanges offer more and more pairs of crypto trading. The reason they are doing it is because the competition is big, and they want to offer more and more than the competitors.
I am not familiar with algorithmic method to trade on the exchanges. But if you find a broker that offers such pairs on MetaTrader, yes, you can create EAs with EA studio or FSB pro for it. You just need to download the Historical data as I show.